upstream Bioprocessing

Measure CPPs and Metabolites in Real Time. No Multivariate Analysis.
No Modeling.

Critical process parameters (CPPs) impact critical quality attributes (CQAs) and need to be monitored and controlled to ensure the quality of your drug product. With Atlas, you can get fast, accurate measurements of CPPs across your upstream process in 1 minute, without cost-intensive multivariate analysis.

Cell Culture

Nutrients and Metabolites

In mammalian cell culture, suboptimal feeding of glucose can lead to excessive lactate production, which may negatively impact cell growth and viability as well as protein production.

Optimize your process faster with Atlas and measure glucose and lactate in CHO cell culture in real-time

Viable Cell Volume (VCV) and Product Titer

Measuring VCV and product titer provides valuable data that can be used to enhance process understanding, refine bioprocess models, improve scale-up strategies, and develop robust control strategies.

With Atlas you can measure VCV and product titer in CHO cell culture in real-time

Fermentation

Nutrients and Optical Density (OD)

By measuring glycerol levels, feeding strategies can be optimized to ensure that cells have a consistent supply of nutrients, preventing substrate depletion or excess, which can lead to suboptimal growth conditions or inhibitory effects. Similarly, tracking OD helps in adjusting nutrient feeds, aeration, and agitation rates to maintain cells in the desired growth phase, enhancing productivity and yield.

Atlas can quickly measure glycerol and OD in fermentation processes.

Harvest

CPP Monitoring During Cell Harvesting

Cell harvesting is the link from upstream to downstream bioprocessing, and it’s a crucial unit operation involving the removal of cells and impurities can impact further downstream processes.